Arthritis is a medical condition of the joint which is characterized by inflammation. The literal meaning of Arthritis also suggests inflammation of one or more joints, the condition is also accompanied by frequently occurring joint pain (also termed as Arthralgia). Polyarthritis is a condition where three or more joints are inflamed, oligoarthritis when two joints are inflamed and monoarthritis when the single joint is inflamed. There are various types of arthritis; the two very prevalent ones are Osteoarthritis and Rheumatoid Arthritis. Together all these types of arthritis are one of the most common chronic illnesses.
There are many causative factors of arthritis and they mostly depend on the form of arthritis. Injury can lead to Osteoarthritis, abnormalities in metabolism can lead to Gout, hereditary factors, infections can also lead to arthritis and the overactive immune system can lead to Rheumatoid arthritis. The most observable symptoms of arthritis are pain and limited function of joints. Joint stiffness, redness, swelling, pain, and warmth are also the characteristics of arthritis. In large joints like knees, cartilage rubs out and limitation of motion can result from joint damage. Apart from Gout, there are no general food supplements that have much of effect on these conditions. People suffering from gout should avoid food supplements like corn syrup, seafood, shellfish, organ meats (which have high purine content), and alcoholic beverages.
Medrol 4mg tablet is a potent and effective medication that is used for the treatment of various inflammatory conditions such as Gout, Arthritis, Osteoarthritis, Multiple Sclerosis, Asthma, COPD and various dermatological conditions. The drug had a deep impact on inflammation and reduces the pain, swelling, redness, and heat arising from either the joints or other inflamed parts. Medrol works faster and effectively as it contains Methylprednisolone as its active therapeutic ingredient that is a corticosteroid medication, it also features in WHO list of essential medication.
Methylprednisolone has high affinity towards specific cytoplasm receptors, after binding, it alters the transcription and protein synthesis process, thereby inhibiting the leukocyte infiltration and other inflammatory mediators and reducing inflammation. The other mode of action of Methylprednisolone is through the blockade of Phospholipase-A2, lipocortins, etc which the mainstay of flaring and promoting inflammation are.
Medrol is available in multiple dosing strengths of 4, 16 and 32mg which should be taken orally with water. The most preferred dose of Medrol for the management of RA is 4 to 48 mg orally once a day or taken in divided doses. The therapy for Gout is usually started with 4 to 48 mg orally once a day. For the management of acute exacerbations of multiple sclerosis a dose of 200 mg of Methylprednisolone is required for a week which is then reduced to 80 mg every other day for 1 month have been shown to be effective. The dose provided here is only initial dose, it is not meant to be taken as an alternative towards doctor’s prescription.
The most commonly occurring side effects of this medication are weight gains, tarry stools, cramps, constipation and increased urination.
- This drug is a steroid preparation and if used for long, it can weaken your immune system, making you prone to infections. These can also worsen an infection you already have.
- Talk to your doctor if you have Diabetes and are using this medication as it can increase the blood glucose level.
- It is unclear whether this drug can harm an unborn baby, have a discussion with your doctor if you are using this medication and are pregnant or planning to get pregnant.
- It is yet not clear whether this drug passes into the breast milk, ask your doctor to know more if you are a breastfeeding
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